Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 10/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365763 | 0.93 | SCN9A (0.43) | MAPK1MALT1IP6K1SCN9ASCN5A | |
| SCHEMBL364379 | 0.89 | LRRK2 (0.38) | MAPK1MALT1ACACBIP6K1SCN9A | |
| SCHEMBL16175423 | 0.86 | SSTR4 (0.41) | MALT1 | |
| SCHEMBL16175604 | 0.86 | IP6K1 (0.42) | IP6K1SCN9A | |
| SCHEMBL20265434 | 0.82 | MALT1 (0.39) | MALT1ACACBIP6K1SCN9ASCN5A | |
| SCHEMBL18013376 | 0.79 | MALT1 (0.39) | MALT1ACACBIP6K1SCN9ASCN5A | |
| SCHEMBL15599224 | 0.79 | SSTR4 (0.41) | MALT1ACACBIP6K1SCN9ASCN5A | |
| SCHEMBL29848256 | 0.76 | LMNA (0.46) | MAPK1IP6K1LMNACYP2C9TSHR | |
| SCHEMBL15093793 | 0.76 | SCN9A (0.42) | MAPK1SCN9ASCN5A | |
| SCHEMBL15599200 | 0.75 | ACACB (0.43) | MALT1ACACBIP6K1SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |