Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987372 | 0.86 | TSHR (0.75) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL16178581 | 0.83 | TSHR (0.53) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL9213028 | 0.82 | TSHR (0.50) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL16178523 | 0.81 | KDM4E (0.66) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL16178557 | 0.80 | TSHR (0.50) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL9217592 | 0.80 | NPSR1 (0.69) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL27517088 | 0.79 | KDM4E (0.68) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL9117834 | 0.76 | TSHR (0.47) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL14986934 | 0.75 | TSHR (0.63) | TSHRHSD17B10HPGDNPSR1KDM4E | |
| SCHEMBL11784507 | 0.74 | TSHR (0.54) | TSHRHSD17B10HPGDNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782573-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | RICHTER GEDEON NYRT (HU) | 2019-10-09 | — | — | EP | claimed |
| US-20140315893-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | RICHTER GEDEON NYRT. (HU) | 2014-10-23 | — | — | US | claimed |
| US-10660789-B2 | 1,4-dihydropyridine derivatives with HSP modulating activity | RICHTER GEDEON NYRT. (HU) | 2020-05-26 | — | — | US | disclosed |
| EP-2782573-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | RICHTER GEDEON NYRT (HU) | 2019-10-09 | — | — | EP | disclosed |
| US-20190192336-A1 | 1,4-Dihydropyridine Derivatives With HSP Modulating Activity | LIPIDART KUTATÓ FEJLESZTO ÉS TANÁCSADÓ KFT. (HU) | 2019-06-27 | — | — | US | disclosed |
| US-10258498-B2 | 1,4-dihydropyridine derivatives with Hsp modulating activity | RICHTER GEDEON NYRT. (HU) | 2019-04-16 | — | — | US | disclosed |
| US-20140315893-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | RICHTER GEDEON NYRT. (HU) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315893-A1 | 1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885HPGD 262/4885 |
| US-10258498-B2 | 1,4-dihydropyridine derivatives with Hsp modulating activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885HPGD 262/4885 |
| US-10660789-B2 | 1,4-dihydropyridine derivatives with HSP modulating activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885HPGD 262/4885 |
| US-20190192336-A1 | 1,4-Dihydropyridine Derivatives With HSP Modulating Activity | HSF1, HSPB1, HSP90AB1 | TSHR 3760/4885HSD17B10 1168/4885HPGD 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.