Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.79 |
| ▸ | MEN1 | O00255 | 6/20 | 0.79 |
| ▸ | RAB9A | P51151 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.60 |
| ▸ | TUBB | P07437 | 7/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16180704 | 1.00 | MAPT (0.79) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL17576070 | 0.89 | MAPT (0.79) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL2526641 | 0.86 | MAPT (0.74) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL2526639 | 0.86 | MAPT (0.74) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6493243 | 0.83 | MEN1 (0.70) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL6493241 | 0.83 | MEN1 (0.70) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL23111697 | 0.83 | MAPT (0.77) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL19695963 | 0.83 | MAPT (0.77) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL9516881 | 0.81 | MAPT (0.66) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL9516889 | 0.81 | MAPT (0.66) | MAPTKMT2AMEN1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100029-B2 | Combretastatin analogs | BIOVENTURES, LLC (US) | 2018-10-16 | — | — | US | disclosed |
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2018-05-03 | — | — | US | disclosed |
| US-9884842-B2 | Combretastatin analogs | BIOVENTURES, LLC (US) | 2018-02-06 | — | — | US | disclosed |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | BIOVENTURES, LLC | 2016-03-10 | — | — | US | disclosed |
| EP-2986596-A2 | COMBRETASTATIN ANALOGS | The Board of Trustees of the University of Arkansas (US) | 2016-02-24 | — | — | EP | disclosed |
| WO-2014172363-A2 | COMBRETASTATIN ANALOGS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2014-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118710-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | MAPT 3070/4885KMT2A 3203/4885MEN1 861/4885 |
| US-10100029-B2 | Combretastatin analogs | HDAC6, HDAC11, HDAC5 | MAPT 3070/4885KMT2A 3203/4885MEN1 861/4885 |
| US-20160068506-A1 | COMBRETASTATIN ANALOGS | HDAC6, HDAC11, HDAC5 | MAPT 3070/4885KMT2A 3203/4885MEN1 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.