Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683810 | 0.86 | MAPT (0.65) | KMT2AMEN1NPC1L3MBTL1KLF5 | |
| SCHEMBL21192738 | 0.86 | MAPT (0.65) | KMT2AMEN1NPC1L3MBTL1KLF5 | |
| SCHEMBL21145646 | 0.79 | MAPT (0.61) | KMT2AMEN1NPC1L3MBTL1KLF5 | |
| SCHEMBL684559 | 0.79 | MAPT (0.61) | KMT2AMEN1NPC1L3MBTL1KLF5 | |
| SCHEMBL684648 | 0.77 | KDM1A (0.58) | KMT2AMEN1NPC1L3MBTL1KLF5 | |
| SCHEMBL7750457 | 0.76 | ERN1 (0.54) | ERN1KMT2AMEN1NPC1L3MBTL1 | |
| SCHEMBL5573608 | 0.76 | ERN1 (0.54) | ERN1KMT2AMEN1NPC1L3MBTL1 | |
| SCHEMBL7750450 | 0.76 | ERN1 (0.54) | ERN1KMT2AMEN1NPC1L3MBTL1 | |
| SCHEMBL5573616 | 0.76 | ERN1 (0.54) | ERN1KMT2AMEN1NPC1L3MBTL1 | |
| SCHEMBL12416703 | 0.76 | MAPT (0.70) | ERN1KMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-8865901-B2 | Gain-of-function Bcl-2 inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | ERN1 2732/4885ADORA2A 1942/4885KMT2A 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.