Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.47 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163070 | 0.89 | DGAT1 (0.59) | DGAT1KCNJ6KCNJ5KCNJ3KDR | |
| SCHEMBL162577 | 0.89 | DGAT1 (0.56) | DGAT1KDRTEKKITCNR1 | |
| SCHEMBL163741 | 0.88 | DGAT1 (0.48) | DGAT1KCNJ6KCNJ5KCNJ3KDR | |
| SCHEMBL158327 | 0.88 | DGAT1 (0.47) | DGAT1KDREPHB4TEKEGFR | |
| SCHEMBL163071 | 0.86 | DGAT1 (0.44) | DGAT1KCNJ6KCNJ5KCNJ3KDR | |
| SCHEMBL173959 | 0.80 | DGAT1 (0.60) | DGAT1NPC1RAB9ASMN1; SMN2CNR1 | |
| SCHEMBL165743 | 0.79 | DGAT1 (0.73) | DGAT1KDRCNR1 | |
| SCHEMBL162997 | 0.79 | DGAT1 (0.55) | DGAT1KDR | |
| SCHEMBL160661 | 0.79 | DGAT1 (0.59) | DGAT1KDRPDGFRB | |
| SCHEMBL161764 | 0.79 | DGAT1 (0.55) | DGAT1KDRTEKPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | claimed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | claimed |