Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177414 | 1.00 | USP30 (0.46) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL16177340 | 0.90 | USP30 (0.45) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL16177338 | 0.90 | USP30 (0.45) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL17679166 | 0.89 | USP30 (0.41) | USP30GPR119PCSK9FPR2 | |
| SCHEMBL17679163 | 0.88 | PCSK9 (0.44) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL16177743 | 0.87 | PCSK9 (0.47) | PCSK9KCNH2 | |
| SCHEMBL16187372 | 0.85 | KCNH2 (0.49) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL16187375 | 0.85 | USP30 (0.46) | USP30GPR119PCSK9MEN1KMT2A | |
| SCHEMBL27200999 | 0.85 | USP30 (0.51) | USP30GPR119MEN1KMT2A | |
| SCHEMBL27200993 | 0.85 | USP30 (0.51) | USP30GPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER (US) | 2016-03-03 | — | — | US | disclosed |
| US-9227956-B2 | Substituted amide compounds | PFIZER INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-9227956-B2 | Substituted amide compounds | PFIZER INC. (US) | 2016-01-05 | — | — | US | disclosed |
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315928-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | USP30 2477/4885GPR119 177/4885PCSK9 35/4885 |
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | USP30 2477/4885GPR119 177/4885PCSK9 35/4885 |
| US-20160058768-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | USP30 2477/4885GPR119 177/4885PCSK9 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.