Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CDK1 | P06493 | 7/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.38 |
| ▸ | CDK4 | P11802 | 6/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.38 |
| ▸ | CCND1 | P24385 | 5/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471834 | 0.84 | MAPK8 (0.38) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL3472713 | 0.84 | IKBKB (0.41) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4478692 | 0.80 | KCNH2 (0.35) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4488346 | 0.76 | CDK4 (0.37) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4489766 | 0.76 | IKBKB (0.45) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4488019 | 0.75 | MEN1 (0.48) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL3477574 | 0.74 | IKBKB (0.41) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4487091 | 0.73 | ALOX15 (0.38) | CDK2CCNA2MAPK8MAPK9MAPK10 | |
| SCHEMBL4477031 | 0.72 | IKBKB (0.40) | CDK2CDK1CCNB1CDK4CCNA2 | |
| SCHEMBL4491100 | 0.72 | MAPK8 (0.68) | CDK2CDK1CCNB1CCNA2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615898-B1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2014-10-29 | — | — | EP | disclosed |