Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619299 | 1.00 | KCNH2 (0.60) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1619343 | 0.95 | KCNH2 (0.62) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4142335 | 0.89 | KCNH2 (0.63) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4134165 | 0.89 | KCNH2 (0.63) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1619268 | 0.88 | KCNH2 (0.51) | KCNH2MEN1HRH2HRH1HRH3 | |
| SCHEMBL1618052 | 0.87 | KCNH2 (0.48) | KCNH2MEN1KDM4EHRH2HRH1 | |
| SCHEMBL1619412 | 0.85 | KCNH2 (0.50) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4137999 | 0.85 | KCNH2 (0.65) | KCNH2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1619267 | 0.84 | KCNH2 (0.48) | KCNH2KMT2AKDM4EALDH1A1MAPK1 | |
| SCHEMBL1619251 | 0.84 | KCNH2 (0.48) | KCNH2KDM4EMAPK1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928225-B2 | Oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2011-04-19 | — | — | US | disclosed |