Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197245 | 0.85 | BRD4 (0.52) | BRD4LMNAPOLBCASP6MEN1 | |
| SCHEMBL24281860 | 0.79 | HTT (0.56) | BRD4LMNAPOLBCASP6MEN1 | |
| SCHEMBL24281278 | 0.78 | POLB (0.65) | BRD4LMNAPOLBCASP6MEN1 | |
| SCHEMBL28519633 | 0.77 | KMT2A (0.40) | LMNAPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5472848 | 0.74 | PIM1 (0.59) | LMNAMEN1KMT2APKMCYP2C19 | |
| SCHEMBL27400418 | 0.74 | BRD4 (0.48) | BRD4LMNAPOLBCASP6MEN1 | |
| SCHEMBL31727514 | 0.73 | BRD4 (0.40) | BRD4LMNAPOLBCASP6KMT2A | |
| SCHEMBL13284255 | 0.73 | USP2 (0.67) | MEN1KMT2AALDH1A1PKMTP53 | |
| SCHEMBL2499492 | 0.72 | BRD4 (0.57) | BRD4LMNAPOLBCASP6MEN1 | |
| SCHEMBL543298 | 0.72 | PDK2 (0.44) | MEN1KMT2AALDH1A1TP53AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989096-B1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE LTD (KY) | 2019-04-10 | — | — | EP | disclosed |
| EP-2989096-B1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE LTD (KY) | 2019-04-10 | — | — | EP | disclosed |
| US-9827226-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2017-11-28 | — | — | US | disclosed |
| US-9827226-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2017-11-28 | — | — | US | disclosed |
| US-9827226-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2017-11-28 | — | — | US | disclosed |
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2017-02-02 | — | — | US | disclosed |
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2017-02-02 | — | — | US | disclosed |
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2017-02-02 | — | — | US | disclosed |
| US-9393232-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2016-07-19 | — | — | US | disclosed |
| US-9393232-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2016-07-19 | — | — | US | disclosed |
| US-9393232-B2 | Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones | BEIGENE, LTD. (KY) | 2016-07-19 | — | — | US | disclosed |
| EP-2989096-A1 | SUBSTITUTED5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BeiGene, Ltd. (KY) | 2016-03-02 | — | — | EP | disclosed |
| US-20160030395-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20160030395-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2016-02-04 | — | — | US | disclosed |
| US-20160030395-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEONE MEDICINES I GMBH (CH) | 2016-02-04 | — | — | US | disclosed |
| WO-2014173241-A1 | SUBSTITUTED5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE, LTD. (GB) | 2014-10-30 | — | — | WO | disclosed |
| WO-2014173241-A1 | SUBSTITUTED5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BEIGENE, LTD. (GB) | 2014-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170027912-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BRD4, BRPF3, BRD3 | BRD4 1/4885LMNA 1590/4885POLB 569/4885 |
| US-20160030395-A1 | SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES | BRD4, BRPF3, BRD3 | BRD4 1/4885LMNA 1590/4885POLB 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.