Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28528531 | 0.86 | LMNA (0.42) | KMT2AMAPTCYP2C19CYP1A2AKR1B1 | |
| SCHEMBL28515905 | 0.86 | SLC27A2 (0.46) | KMT2AMAPTCYP2C19AKR1B1LMNA | |
| SCHEMBL29619573 | 0.86 | SLC27A2 (0.46) | KMT2AMAPTCYP2C19AKR1B1LMNA | |
| SCHEMBL29619589 | 0.85 | ADAMTS5 (0.39) | KMT2AMAPTCYP2C19CYP1A2AKR1B1 | |
| SCHEMBL29619616 | 0.78 | LMNA (0.40) | KMT2AMAPTCYP2C19CYP1A2AKR1B1 | |
| SCHEMBL16197051 | 0.77 | BRD4 (0.54) | KMT2ACYP2C19AKR1B1AKR1A1LMNA | |
| SCHEMBL28522164 | 0.76 | TP53 (0.42) | KMT2AMAPTAKR1B1LMNAPKM | |
| SCHEMBL28526734 | 0.76 | LMNA (0.42) | KMT2AMAPTCYP2C19LMNAPKM | |
| SCHEMBL1966160 | 0.73 | CYP1A2 (0.54) | KMT2AMAPTCYP2C19CYP1A2AKR1B1 | |
| SCHEMBL29619619 | 0.72 | ALDH1A1 (0.52) | KMT2AMAPTLMNAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112250614-B | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2022-02-01 | — | — | CN | disclosed |
| CN-112250614-A | Synthesis method of 3-spiro-tricyclic indolone derivative | 苏州大学 | 2021-01-22 | — | — | CN | disclosed |