Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797448 | 0.81 | HTR2A (0.75) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16208329 | 0.81 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL30585519 | 0.78 | SIGMAR1 (0.50) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL22528277 | 0.78 | SIGMAR1 (0.50) | SIGMAR1HTR2AHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL8986182 | 0.77 | HTR2A (0.54) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16208335 | 0.77 | HTR2A (0.66) | SIGMAR1HTR2AHTR2CHTR1A | |
| Hydrochloric Acid SCHEMBL16197598 | 0.76 | HTR2A (0.64) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16197727 | 0.75 | SIGMAR1 (0.58) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16197830 | 0.75 | SIGMAR1 (0.69) | SIGMAR1HTR2AHTR2CHTR1A | |
| SCHEMBL16197666 | 0.75 | SIGMAR1 (0.63) | SIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989105-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014173903-A1 | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-10-30 | — | — | WO | disclosed |