Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199098 | 1.00 | FLT3 (0.39) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL15401452 | 0.90 | SMYD3 (0.34) | — | |
| SCHEMBL15399985 | 0.89 | GRM5 (0.38) | AURKAAURKB | |
| SCHEMBL16199395 | 0.86 | GSK3A (0.38) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL16199392 | 0.82 | GSK3A (0.41) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL16199019 | 0.82 | GSK3A (0.38) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL15400687 | 0.82 | GSK3A (0.42) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL17518514 | 0.82 | FLT3 (0.45) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL15399800 | 0.81 | GSK3A (0.39) | FLT3GSK3AGSK3BJAK2SRC | |
| SCHEMBL16199025 | 0.81 | GSK3A (0.39) | FLT3GSK3AGSK3BJAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871774-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-28 | — | — | US | disclosed |