Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 3/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 9/20 | 0.51 |
| ▸ | ITK | Q08881 | 9/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857051 | 0.92 | KIT (0.57) | PLCG1RIPK1BTKITKKIT | |
| SCHEMBL14620675 | 0.88 | BTK (0.53) | PLCG1RIPK1BTKITKKIT | |
| SCHEMBL857973 | 0.85 | AXL (0.64) | RIPK1AAK1NEK1AXLCYP2D6 | |
| SCHEMBL857556 | 0.82 | NTRK1 (0.57) | RIPK1BTKITKKITNTRK1 | |
| SCHEMBL856965 | 0.81 | AAK1 (0.48) | PLCG1RIPK1BTKITKKIT | |
| SCHEMBL856981 | 0.81 | AAK1 (0.52) | RIPK1KITAAK1NTRK1NEK1 | |
| SCHEMBL857930 | 0.79 | NTRK1 (0.60) | PLCG1RIPK1BTKITKKIT | |
| SCHEMBL4016727 | 0.78 | AXL (0.66) | AAK1NEK1AXLCYP2D6 | |
| SCHEMBL415590 | 0.78 | KIT (0.61) | PLCG1RIPK1BTKITKKIT | |
| SCHEMBL412758 | 0.77 | KIT (0.63) | PLCG1RIPK1BTKITKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-B1 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2014-10-29 | — | — | EP | disclosed |