Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.66 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857666 | 0.88 | AXL (0.61) | AXLAAK1PDGFRBPDGFRACYP2C9 | |
| SCHEMBL857790 | 0.88 | AXL (0.64) | AXLAAK1PDGFRBPDGFRACYP2C9 | |
| SCHEMBL857973 | 0.87 | AXL (0.64) | AXLAAK1CYP2D6PAK1NEK1 | |
| SCHEMBL858514 | 0.85 | AAK1 (0.46) | AXLAAK1CYP2D6CYP2C9CDK8 | |
| SCHEMBL856981 | 0.83 | AAK1 (0.52) | AXLAAK1CYP2D6CYP2C9PAK1 | |
| SCHEMBL857953 | 0.83 | AXL (0.64) | AXLAAK1PDGFRBPDGFRACYP2C9 | |
| SCHEMBL857793 | 0.83 | AXL (0.67) | AXLAAK1CDK8NEK1 | |
| SCHEMBL4014735 | 0.82 | AXL (0.64) | AXLAAK1PDGFRBPDGFRACYP2D6 | |
| SCHEMBL857286 | 0.81 | BRAF (0.52) | AXLAAK1PDGFRBPDGFRACYP2D6 | |
| SCHEMBL857051 | 0.81 | KIT (0.57) | AXLAAK1CYP2D6NEK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504509-B2 | Compounds and methods for development of Ret modulators | PLEXXIKON, INC. (US) | 2009-03-17 | — | — | US | claimed |