Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28798289 | 0.94 | MAPKAPK2 (0.49) | MAPTKDM4EGAAMAPKAPK2LMNA | |
| SCHEMBL31633231 | 0.86 | MAPT (0.45) | MAPTKDM4EGAAMAPKAPK2LMNA | |
| SCHEMBL1622661 | 0.82 | MAPT (0.43) | MAPTKDM4EGAAMAPKAPK2LMNA | |
| SCHEMBL9235864 | 0.80 | NPC1 (0.44) | MAPTKDM4EGAAMAPKAPK2LMNA | |
| SCHEMBL19934034 | 0.80 | MAPT (0.60) | MAPTKDM4EGAALMNAHTT | |
| SCHEMBL16252949 | 0.78 | MAPT (0.39) | MAPTKDM4EGAALMNAHTT | |
| SCHEMBL31344821 | 0.76 | MAPKAPK2 (0.41) | MAPTMAPKAPK2SMN1; SMN2RAB9A | |
| SCHEMBL16199552 | 0.74 | MAPT (0.36) | MAPTKDM4EGAALMNAHTT | |
| SCHEMBL16199569 | 0.74 | KMT2A (0.38) | MAPTKDM4EGAALMNAHTT | |
| SCHEMBL16199562 | 0.74 | MAPK1 (0.47) | MAPTKDM4EGAALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796461-B1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO LTD (CN) | 2017-09-06 | — | — | EP | disclosed |
| US-9085588-B2 | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2015-07-21 | — | — | US | disclosed |
| US-9085588-B2 | Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2015-07-21 | — | — | US | disclosed |
| US-8916652-B2 | Multi-armed catechol compound blends | KENSEY NASH CORPORATION (US) | 2014-12-23 | — | — | US | disclosed |
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| EP-2796461-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | Beta Pharmaceuticals Co., Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343283-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | ABL1, JAK2, ALK | MAPT 2646/4885KDM4E 2328/4885GAA 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.