Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31633231 | 0.82 | MAPT (0.45) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL16252949 | 0.77 | MAPT (0.39) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL9235864 | 0.75 | NPC1 (0.44) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL28798262 | 0.74 | KDM4E (0.60) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL16199533 | 0.74 | MAPT (0.47) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL16199552 | 0.73 | MAPT (0.36) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL15981873 | 0.71 | MAPT (0.37) | KMT2AMAPTLMNAHTTBLM | |
| SCHEMBL16199562 | 0.70 | MAPK1 (0.47) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL16252950 | 0.70 | KDM4E (0.36) | KMT2ARAB9ANPC1MAPTLMNA | |
| SCHEMBL16199536 | 0.70 | MAPT (0.34) | KMT2ARAB9ANPC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796461-A1 | METHODS OF PREPARING ICOTINIB AND ICOTINIB HYDROCHLORIDE, AND INTERMEDIATES THEREOF | Beta Pharmaceuticals Co., Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |