Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467312 | 0.92 | TAAR1 (0.46) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL27017158 | 0.84 | TAAR1 (0.47) | TAAR1ALDH1A1MAPK1 | |
| SCHEMBL16200380 | 0.83 | TAAR1 (0.53) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL14309294 | 0.83 | TAAR1 (0.63) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL13067431 | 0.83 | TAAR1 (0.50) | TAAR1GAAALDH1A1KDM4EMAPT | |
| SCHEMBL13067437 | 0.81 | TAAR1 (0.52) | TAAR1GAAALDH1A1KDM4EMAPT | |
| SCHEMBL12467391 | 0.79 | TAAR1 (0.53) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL21233362 | 0.79 | TAAR1 (0.53) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL16200094 | 0.78 | TAAR1 (0.53) | TAAR1GAANPC1ALDH1A1KDM4E | |
| SCHEMBL383766 | 0.78 | GAA (0.54) | TAAR1GAANPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |