Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | PPOX | P50336 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844024 | 0.85 | TAAR1 (0.54) | TAAR1PPOXALDH1A1GAAKDM4E | |
| SCHEMBL5774184 | 0.85 | TAAR1 (0.53) | TAAR1PPOXALDH1A1GAAKDM4E | |
| SCHEMBL13618030 | 0.84 | TAAR1 (0.53) | TAAR1HMGCR | |
| SCHEMBL6739489 | 0.83 | TAAR1 (0.51) | TAAR1PPOXGAANPC1MAPT | |
| SCHEMBL6738129 | 0.83 | TAAR1 (0.51) | TAAR1PPOXALDH1A1GAAKDM4E | |
| SCHEMBL8848996 | 0.82 | TAAR1 (0.47) | TAAR1PPOXALDH1A1GAAKDM4E | |
| SCHEMBL16200380 | 0.82 | TAAR1 (0.53) | TAAR1ALDH1A1GAAKDM4ENPC1 | |
| SCHEMBL7720458 | 0.82 | TAAR1 (0.62) | TAAR1HMGCR | |
| SCHEMBL14309294 | 0.82 | TAAR1 (0.63) | TAAR1ALDH1A1GAAKDM4ENPC1 | |
| SCHEMBL21139133 | 0.80 | TAAR1 (0.49) | TAAR1PPOXALDH1A1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |