Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PPOX | P50336 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19088271 | 0.86 | PPOX (0.46) | KDM4ECYP1A2CYP2C19MAPTPPOX | |
| SCHEMBL19088273 | 0.84 | PPOX (0.45) | KDM4ECYP1A2CYP2C19MAPTPPOX | |
| SCHEMBL30805782 | 0.84 | KDM4E (0.51) | KDM4ECYP1A2CYP2C19MAPTTSHR | |
| SCHEMBL12129123 | 0.84 | KDM4E (0.51) | KDM4ECYP1A2CYP2C19MAPTTSHR | |
| SCHEMBL19123074 | 0.82 | HTT (0.45) | KDM4ECYP1A2CYP2C19MAPTTSHR | |
| SCHEMBL18304662 | 0.82 | KDM1A (0.41) | KDM4ECYP1A2CYP2C19MAPTTSHR | |
| SCHEMBL19088275 | 0.80 | PPOX (0.42) | KDM4ECYP1A2CYP2C19MAPTPPOX | |
| SCHEMBL8599602 | 0.79 | PPOX (0.45) | KDM4ECYP1A2CYP2C19MAPTPPOX | |
| SCHEMBL8157623 | 0.79 | KDM4E (0.49) | KDM4ECYP1A2CYP2C19MAPTTSHR | |
| SCHEMBL19156087 | 0.78 | KDM1A (0.41) | KDM4ECYP1A2CYP2C19MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |