Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683059 | 0.80 | ADORA1 (0.40) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL16200167 | 0.79 | BRD4 (0.35) | KDM4ELMNAPOLBBLMNPC1 | |
| SCHEMBL16200286 | 0.77 | NPC1 (0.45) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL7250905 | 0.75 | MAPT (0.50) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL13184354 | 0.75 | KDM4E (0.43) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL10514864 | 0.74 | CA9 (0.44) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL17159707 | 0.73 | KDM4E (0.41) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL27519517 | 0.71 | PDE2A (0.46) | KDM4ECCR1CCR5CCR8NPC1 | |
| SCHEMBL13430363 | 0.70 | KDM4E (0.45) | KDM4ELMNAPOLBBLMCCR1 | |
| SCHEMBL31221234 | 0.70 | BRD4 (0.43) | KDM4ELMNAPOLBBLMCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |