Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27519517 | 0.88 | PDE2A (0.46) | MAPTGRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5255885 | 0.79 | MAPT (0.56) | MAPTCDK8ACVR1NPC1RAB9A | |
| SCHEMBL16200166 | 0.75 | KDM4E (0.42) | MAPTGRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14996573 | 0.73 | MAPT (0.52) | MAPTCDK8ACVR1GRM5NPC1 | |
| SCHEMBL8138943 | 0.71 | KDR (0.48) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL11591603 | 0.71 | NPC1 (0.67) | MAPTGRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4158211 | 0.70 | MAPT (0.49) | MAPTCDK8ACVR1NPC1RAB9A | |
| SCHEMBL7755885 | 0.70 | MAPT (0.49) | MAPTCDK8ACVR1GRM5NPC1 | |
| SCHEMBL11656557 | 0.70 | MAPT (0.58) | MAPTCDK8ACVR1NPC1RAB9A | |
| SCHEMBL13184354 | 0.70 | KDM4E (0.43) | MAPTGRM5NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617324-B1 | Phenyl, cyclohexyl and pyridinyl or pyrimidinyl-substituted | G. D. SEARLE & COMPANY | 2003-09-09 | — | — | US | disclosed |