Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CRHBP | P24387 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.48 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29041058 | 0.83 | MEN1 (0.50) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL16200211 | 0.80 | MEN1 (0.48) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL13860722 | 0.77 | MAPT (0.51) | MAPK1MEN1KMT2ACASP1CASP7 | |
| SCHEMBL16200208 | 0.76 | MAPK1 (0.44) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL6198110 | 0.76 | TSHR (0.50) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL6199678 | 0.75 | KDR (0.58) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL13858541 | 0.75 | KDM4E (0.49) | MAPK1MEN1KMT2ACRHBPCASP1 | |
| SCHEMBL13860520 | 0.74 | NPC1 (0.53) | MEN1KMT2AKDM4ECA1CA2 | |
| SCHEMBL14015683 | 0.73 | RET (0.44) | KMT2ASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL17322911 | 0.69 | HSD17B10 (0.64) | MAPK1MEN1KMT2ACRHBPCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |