Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18988262 | 0.85 | ADORA1 (0.47) | TSHRADORA1ADORA2AGAAALDH1A1 | |
| SCHEMBL6881906 | 0.84 | TSHR (0.68) | TSHRADORA1ADORA2AGAALMNA | |
| SCHEMBL4059086 | 0.83 | PDE4A (0.51) | ADORA1ADORA2ALMNAALDH1A1TDP1 | |
| SCHEMBL24411612 | 0.82 | DGAT1 (0.40) | TSHRGAALMNAALDH1A1KDM4E | |
| SCHEMBL17173942 | 0.80 | LMNA (0.56) | ADORA1ADORA2ALMNAALDH1A1TDP1 | |
| SCHEMBL17726080 | 0.79 | ADORA1 (0.43) | TSHRADORA1ADORA2ALMNAALDH1A1 | |
| SCHEMBL29041058 | 0.79 | MEN1 (0.50) | TSHRADORA1GAALMNAALDH1A1 | |
| SCHEMBL8916000 | 0.78 | TSHR (0.67) | TSHRADORA1ADORA2AGAALMNA | |
| SCHEMBL27847239 | 0.78 | ADORA1 (0.54) | ADORA1ADORA2ALMNAALDH1A1TDP1 | |
| SCHEMBL16200211 | 0.76 | MEN1 (0.48) | TSHRADORA1GAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |