Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257770 | 0.72 | CHEK1 (0.49) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1903235 | 0.70 | PDE10A (0.45) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL16200249 | 0.69 | FYN (0.38) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL12067000 | 0.68 | PDE10A (0.40) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL16882346 | 0.68 | MAPT (0.53) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27512201 | 0.68 | KDM4E (0.50) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL16200261 | 0.68 | PIK3CD (0.45) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL569677 | 0.68 | POLB (0.49) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL569614 | 0.67 | PDE10A (0.45) | PDE10AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3464307 | 0.66 | MAPK14 (0.40) | TDP1POLBLMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |