Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184317 | 0.80 | MEN1 (0.47) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL13184249 | 0.80 | SLC6A4 (0.49) | KDM4EGAAALDH1A1TAAR1 | |
| SCHEMBL16200315 | 0.78 | KMT2A (0.58) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL13178799 | 0.75 | KMT2A (0.55) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL13262991 | 0.73 | KDM1A (0.60) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL19650826 | 0.73 | KMT2A (0.57) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL4630869 | 0.72 | MEN1 (0.62) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL737379 | 0.72 | KMT2A (0.50) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL12467391 | 0.71 | TAAR1 (0.53) | KDM4EGAAALDH1A1MAPTTAAR1 | |
| SCHEMBL21233362 | 0.71 | TAAR1 (0.53) | KDM4EGAAALDH1A1MAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |