Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178799 | 0.82 | KMT2A (0.55) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL14036538 | 0.80 | KDM1A (0.57) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL16200316 | 0.78 | KMT2A (0.52) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL13178806 | 0.77 | SLC6A4 (0.48) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL13184317 | 0.76 | MEN1 (0.47) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL16200311 | 0.76 | MAPT (0.42) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL14036621 | 0.75 | MEN1 (0.49) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL11782294 | 0.75 | MEN1 (0.64) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL11684657 | 0.74 | KMT2A (0.67) | KMT2AMEN1KDM4EHTTGAA | |
| SCHEMBL16200298 | 0.74 | ALDH1A1 (0.47) | KMT2AMEN1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |