Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.30 |
| ▸ | GYS1 | P13807 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464192 | 0.73 | LRRK2 (0.43) | MAPK1 | |
| SCHEMBL2875179 | 0.71 | AKT2 (0.50) | HCAR2GAAMAPTALOX15KMT2A | |
| SCHEMBL13162522 | 0.69 | HPGDS (0.45) | HCAR2PRMT5WDR77IKBKBMAP3K14 | |
| SCHEMBL16200321 | 0.69 | HCAR2 (0.33) | HCAR2IKBKBMAP3K14GYS1MEN1 | |
| SCHEMBL3465241 | 0.69 | CHEK1 (0.43) | IKBKBMAP3K14GYS1MEN1CYP1A2 | |
| SCHEMBL2614356 | 0.68 | IKBKB (0.50) | IKBKBMAP3K14GYS1MEN1CYP1A2 | |
| SCHEMBL3465575 | 0.68 | MAPK1 (0.47) | MAPK1 | |
| SCHEMBL3464003 | 0.68 | MAP2K4 (0.55) | CYP1A2CYP3A4 | |
| SCHEMBL16200308 | 0.68 | AXL (0.52) | MAPK1 | |
| SCHEMBL24119890 | 0.67 | ERBB2 (0.45) | IKBKBMAP3K14GYS1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |