Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.79 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 10/20 | 0.62 |
| ▸ | RAB9A | P51151 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998929 | 0.89 | PDE11A (1.00) | PDE11APDE10AMAPTKDM4EHSD17B10 | |
| SCHEMBL16201551 | 0.88 | PDE11A (0.84) | PDE11APDE10AMAPTKDM4EHSD17B10 | |
| SCHEMBL29510945 | 0.78 | RAB9A (1.00) | PDE11APDE10AMAPTKDM4EHSD17B10 | |
| SCHEMBL14773948 | 0.78 | RAB9A (1.00) | PDE11APDE10AMAPTKDM4EHSD17B10 | |
| SCHEMBL3604861 | 0.77 | IRAK4 (0.80) | MAPTKDM4EHSD17B10TSHRHTT | |
| SCHEMBL14855681 | 0.77 | F10 (0.72) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL17916715 | 0.76 | RAB9A (0.89) | PDE11APDE10AMAPTKDM4EHSD17B10 | |
| SCHEMBL29870324 | 0.76 | F10 (0.70) | MAPTKDM4ENPC1RAB9ATP53 | |
| SCHEMBL21528226 | 0.76 | F10 (0.70) | MAPTKDM4ENPC1RAB9ATP53 | |
| SCHEMBL21105717 | 0.76 | IRAK4 (1.00) | MAPTKDM4EHSD17B10TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173884-B2 | Inhibitors of phosphodiesterase 11 (PDE11) | TRUSTEES OF BOSTON COLLEGE (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140323503-A1 | INHIBITORS OF PHOSPODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATE CORTISOL PRODUCTION | TRUSTEES OF BOSTON COLLEGE | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323503-A1 | INHIBITORS OF PHOSPODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATE CORTISOL PRODUCTION | PDE12, HSD11B2, PDE7A | PDE11A 24/4885PDE10A 12/4885MAPT 3307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.