Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 14/20 | 0.51 |
| ▸ | F2 | P00734 | 8/20 | 0.51 |
| ▸ | F9 | P00740 | 2/20 | 0.50 |
| ▸ | PLG | P00747 | 2/20 | 0.50 |
| ▸ | PLAT | P00750 | 2/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1770731 | 0.99 | LMNA (0.54) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL1770309 | 0.88 | HPGD (0.51) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL20560085 | 0.78 | F10 (0.53) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL1770395 | 0.78 | F10 (0.53) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL1770887 | 0.77 | MAPK1 (0.52) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL1770888 | 0.77 | MAPK1 (0.52) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL17682014 | 0.77 | MAPK1 (0.59) | LMNAMAPK1KMT2AF10F2 | |
| Hydrochloric Acid SCHEMBL29197847 | 0.76 | MAPK1 (0.51) | LMNAMAPK1KMT2AF10F2 | |
| SCHEMBL1770563 | 0.76 | F10 (0.55) | LMNAF10F2TSHR | |
| SCHEMBL8280724 | 0.72 | MAPK1 (0.59) | LMNAMAPK1KMT2AF10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | disclosed |
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | disclosed |
| US-20160102082-A1 | TARTRATE SALT OF 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID [(S)-2-[METHYL-3-(2-OXO-PYRROLIDIN-1-YL)-BENZENESULFONYLAMINO]-3-(4-METHYL-PIPERAZIN-1-YL)-3-OXO-PROPYL]AMIDE | BEIJING COLLAB PHARM CO., LTD. (CN) | 2016-04-14 | — | — | US | disclosed |
| US-20160102082-A1 | TARTRATE SALT OF 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID [(S)-2-[METHYL-3-(2-OXO-PYRROLIDIN-1-YL)-BENZENESULFONYLAMINO]-3-(4-METHYL-PIPERAZIN-1-YL)-3-OXO-PROPYL]AMIDE | BEIJING COLLAB PHARM CO., LTD. (CN) | 2016-04-14 | — | — | US | disclosed |
| WO-2014174102-A1 | TARTRATE SALT OF 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID [(S)-2-[METHYL-3-(2-OXO-PYRROLIDIN-1-YL)-BENZENESULFONYLAMINO]-3-(4-METHYL PIPERAZIN-1 -YL)-3-OXO-PROPRYL]AMIDE | SANOFI (FR) | 2014-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102082-A1 | TARTRATE SALT OF 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID [(S)-2-[METHYL-3-(2-OXO-PYRROLIDIN-1-YL)-BENZENESULFONYLAMINO]-3-(4-METHYL-PIPERAZIN-1-YL)-3-OXO-PROPYL]AMIDE | CPS1, ACP3, ACP1 | LMNA 4643/4885MAPK1 2423/4885KMT2A 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.