⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15912321 | 0.79 | CYP1A2 (0.30) | — | |
| SCHEMBL16201653 | 0.73 | CDC25A (0.32) | — | |
| SCHEMBL7158411 | 0.70 | — | — | |
| SCHEMBL525595 | 0.70 | — | — | |
| SCHEMBL13562166 | 0.67 | TP53 (0.32) | — | |
| SCHEMBL13326233 | 0.65 | CYP2A6 (0.31) | — | |
| SCHEMBL7635852 | 0.65 | — | — | |
| SCHEMBL25060893 | 0.62 | RNASEH1 (0.36) | — | |
| SCHEMBL3172157 | 0.62 | — | — | |
| SCHEMBL16201624 | 0.62 | CDC25A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9345905-B2 | Heterocyclic amides compounds which are HDAC6 inhibitors and used as anti-tumoral agents | NANJING ALLGEN PHARMA CO. LTD. (CN) | 2016-05-24 | — | — | US | disclosed |
| US-20140322229-A1 | HETEROCYCLIC AMIDES COMPOUNDS WHICH ARE HDAC6 INHIBITORS AND USED AS ANTI-TUMORAL AGENTS | BETA PHARMA CANADA INC. (CA) | 2014-10-30 | — | — | US | disclosed |