Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 4/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | SCN1A | P35498 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12727534 | 0.93 | CACNA1C (0.58) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL16087942 | 0.91 | CACNA1D (0.48) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL13198586 | 0.87 | CACNA1C (0.63) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL18062192 | 0.78 | CACNA1D (0.51) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL11307558 | 0.77 | ADORA3 (0.62) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL12727530 | 0.76 | CACNA1C (0.60) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL7186400 | 0.75 | KMT2A (0.44) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL16089107 | 0.74 | CACNA1C (0.58) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL4608748 | 0.73 | CACNA1C (0.73) | CACNA1CCACNA1DKMT2AADORA3CACNA1F | |
| SCHEMBL612520 | 0.73 | CACNA1C (0.73) | CACNA1CCACNA1DKMT2AADORA3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9132200-B2 | Oligomer-calcium channel blocker conjugates | NEKTAR THERAPEUTICS (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140323529-A1 | OLIGOMER-CALCIUM CHANNEL BLOCKER CONJUGATES | NEKTAR THERAPEUTICS (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323529-A1 | OLIGOMER-CALCIUM CHANNEL BLOCKER CONJUGATES | ORAI1, CACNB2, CACNA1B | CACNA1C 8/4885CACNA1D 18/4885KMT2A 3583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.