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Sugi Predict / Compounds / SCHEMBL16204275

SCHEMBL16204275

SCHEMBL16204275

CNCCN(C)Cc1cn(CCC(O)CO)nc1-c1ccc(F)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.36
▸ MAPT P10636 2/20 0.36
▸ GAA P10253 1/20 0.36
▸ PRMT1 Q99873 6/20 0.36
▸ PRMT6 Q96LA8 2/20 0.36
▸ PRMT8 Q9NR22 1/20 0.36
▸ MAPK14 Q16539 2/20 0.35
▸ AGTR1 P30556 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ CARM1 Q86X55 2/20 0.33
▸ RECQL P46063 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ CSNK1D P48730 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16204174 0.94 KDM4E (0.35) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16204175 0.82 KDM4E (0.43) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16204176 0.79 KDM4E (0.40) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16201328 0.79 KDM4E (0.39) KDM4EMAPTGAAMAPK14AGTR1
SCHEMBL16201167 0.78 KDM4E (0.37) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16204227 0.77 PRMT1 (0.42) PRMT1PRMT6PRMT8MAPK14CARM1
SCHEMBL16201325 0.76 MAPT (0.41) KDM4EMAPTGAAMAPK14AGTR1
SCHEMBL16201157 0.75 MAPT (0.41) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16204229 0.74 PRMT1 (0.39) KDM4EMAPTGAAPRMT1PRMT6
SCHEMBL16204217 0.73 PRMT1 (0.39) KDM4EMAPTGAAPRMT1PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9776972-B2 Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof EPIZYME INC. (US) 2017-10-03 — — US disclosed
US-9732041-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2017-08-15 — — US disclosed
US-20170057926-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2017-03-02 — — US disclosed
US-9346761-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2016-05-24 — — US disclosed
US-20160137609-A1 PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2016-05-19 — — US disclosed
US-20140323537-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-10-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140323537-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 KDM4E 157/4885MAPT 1449/4885GAA 384/4885
US-20170057926-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 KDM4E 157/4885MAPT 1449/4885GAA 384/4885
US-20160137609-A1 PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 KDM4E 288/4885MAPT 1526/4885GAA 738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.