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PRMT3

Protein arginine N-methyltransferase 3 · O60678 · PRMT3 on Sugi Atlas →

11,075 patent compounds predicted against PRMT3, 7,111 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1105034 SCHEMBL1105034 0.54 15/20
SCHEMBL567769 SCHEMBL567769 0.48 14/20
SCHEMBL567803 SCHEMBL567803 0.48 13/20
SCHEMBL2162932 SCHEMBL2162932 0.61 12/20
SCHEMBL1105032 SCHEMBL1105032 0.52 12/20
SCHEMBL1124261 SCHEMBL1124261 0.52 12/20
SCHEMBL1705154 SCHEMBL1705154 0.50 11/20
SCHEMBL1292028 SCHEMBL1292028 0.38 11/20
SCHEMBL1292030 SCHEMBL1292030 0.38 11/20
SCHEMBL1124139 SCHEMBL1124139 0.51 10/20
SCHEMBL1095530 SCHEMBL1095530 0.55 9/20
SCHEMBL1095533 SCHEMBL1095533 0.55 9/20
SCHEMBL1572041 SCHEMBL1572041 0.48 9/20
SCHEMBL2162998 SCHEMBL2162998 0.78 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL111600) 0.62 8/20
SCHEMBL1105016 SCHEMBL1105016 0.53 8/20
SCHEMBL1105029 SCHEMBL1105029 0.53 8/20
SCHEMBL1571968 SCHEMBL1571968 0.52 8/20
SCHEMBL2162755 SCHEMBL2162755 0.60 7/20
SCHEMBL1492799 SCHEMBL1492799 0.59 7/20

Clinical trials — most relevant to PRMT3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study) PHASE3RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors PHASE1/PHASE2RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial PHASE2COMPLETED
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics PHASE2COMPLETED
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors PHASE1RECRUITING
Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors PHASE1COMPLETED
Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma EARLY_PHASE1RECRUITING
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. EARLY_PHASE1COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure nanENROLLING_BY_INVITATION
Patient's Derived Organoids for Drug Screening in Glioblastoma nanNOT_YET_RECRUITING
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment nanUNKNOWN
Study of the Articular Microbiota in Rheumatoid Arthritis. nanCOMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
Preterm Arginine INTake Study nanCOMPLETED
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) nanRECRUITING
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial nanCOMPLETED
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes nanUNKNOWN
Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? nanCOMPLETED
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
A Study of Multilocus Methylation Abnormalities in Subjects With Imprinting Disorders nanNOT_YET_RECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke nanCOMPLETED
DNA Methylation and Perioperative Pain Treatment nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRMT3 binder may also engage these)

ProteinNameSimilarity
Q922H1 — 0.998 Q922H1 →
O70467 — 0.997 O70467 →
O13648 — 0.997 O13648 →
B3M1E1 — 0.993 B3M1E1 →
Q9URX7 — 0.991 Q9URX7 →
A2Z0C0 — 0.990 A2Z0C0 →
Q9MAT5 — 0.990 Q9MAT5 →
Q5D892 — 0.990 Q5D892 →
Q7QIL2 — 0.990 Q7QIL2 →
Q582G4 — 0.989 Q582G4 →
A2Y953 — 0.988 A2Y953 →
Q9D1P2 — 0.988 Q9D1P2 →
Q9R1T4 — 0.988 Q9R1T4 →
A2VDP2 — 0.988 A2VDP2 →
Q9M2Q4 — 0.988 Q9M2Q4 →
P56519 — 0.987 P56519 →
Q6DNF3 — 0.987 Q6DNF3 →
Q66I84 — 0.987 Q66I84 →
Q5JTY5 — 0.987 Q5JTY5 →
Q8LI34 — 0.987 Q8LI34 →
DGKG Diacylglycerol kinase gamma 0.987 landscape →
Q91WQ5 — 0.987 Q91WQ5 →
O75529 — 0.987 O75529 →
P87241 — 0.987 P87241 →
B4P925 — 0.986 B4P925 →
Q2QRX6 — 0.986 Q2QRX6 →
P56517 — 0.986 P56517 →
Q95ZS2 — 0.986 Q95ZS2 →
Q9VX91 — 0.986 Q9VX91 →
SEPTIN8 Septin-8 0.986 landscape →