Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 15/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.64 |
| ▸ | RET | P07949 | 10/20 | 0.61 |
| ▸ | ROS1 | P08922 | 10/20 | 0.61 |
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16206859 | 0.91 | EML4 (0.75) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16206864 | 0.91 | EML4 (0.75) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16206833 | 0.86 | EML4 (0.63) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16206906 | 0.83 | EML4 (0.69) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16258188 | 0.83 | EML4 (0.74) | EML4ALKRETROS1FLT3 | |
| SCHEMBL21915026 | 0.83 | EML4 (0.81) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129732 | 0.83 | ALK (0.76) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16258187 | 0.83 | EML4 (0.74) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129456 | 0.82 | ALK (0.80) | EML4ALKRETROS1FLT3 | |
| SCHEMBL16207117 | 0.82 | EML4 (0.66) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085540-B2 | Pyrazinecarboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | EGFR, ERBB2, ALK | EML4 158/4885ALK 3/4885RET 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.