Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | EML4 | Q9HC35 | 10/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.49 |
| ▸ | RET | P07949 | 5/20 | 0.44 |
| ▸ | ROS1 | P08922 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16206814 | 0.88 | EML4 (0.51) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207061 | 0.87 | EGFR (0.70) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207063 | 0.84 | EGFR (0.68) | EGFREML4ALKRETROS1 | |
| SCHEMBL16195946 | 0.84 | EML4 (0.51) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207064 | 0.83 | EML4 (0.64) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207070 | 0.82 | EGFR (0.54) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207066 | 0.82 | EML4 (0.64) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207062 | 0.81 | EGFR (0.82) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207337 | 0.80 | EML4 (0.66) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207068 | 0.80 | EML4 (0.64) | EGFREML4ALKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085540-B2 | Pyrazinecarboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-9085540-B2 | Pyrazinecarboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-07-21 | — | — | US | disclosed |
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-30 | — | — | US | disclosed |
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323463-A1 | PYRAZINECARBOXAMIDE COMPOUND | EGFR, ERBB2, ALK | EGFR 1/4885EML4 158/4885ALK 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.