Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974201 | 0.87 | HSD11B1 (0.56) | HSD11B1NAMPTLMNAGAAHTT | |
| SCHEMBL16208047 | 0.78 | HSD11B1 (0.60) | HSD11B1LMNAGAAMEN1KMT2A | |
| SCHEMBL16208020 | 0.73 | HSD11B1 (0.66) | HSD11B1 | |
| SCHEMBL16208170 | 0.73 | HSD11B1 (0.76) | HSD11B1 | |
| SCHEMBL16208204 | 0.72 | HSD11B1 (0.65) | HSD11B1 | |
| SCHEMBL16208215 | 0.72 | HSD11B1 (0.62) | HSD11B1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL975640 | 0.72 | HSD11B1 (0.77) | HSD11B1 | |
| SCHEMBL3665887 | 0.72 | HSD11B1 (0.77) | HSD11B1 | |
| SCHEMBL16208025 | 0.72 | HSD11B1 (0.65) | HSD11B1 | |
| SCHEMBL16208161 | 0.71 | HSD11B1 (0.63) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238126-B1 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2014-11-05 | — | — | EP | claimed |