Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 18/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | TXK | P42681 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622508 | 0.80 | ITK (0.61) | ITKLCKTXKSYKRET | |
| SCHEMBL1623341 | 0.79 | ITK (0.63) | ITKLCKTXKSYKCASP3 | |
| SCHEMBL1621145 | 0.77 | ITK (0.54) | ITKLCKTXKSYK | |
| SCHEMBL1622817 | 0.76 | ITK (0.65) | ITKLCKTXKSYK | |
| SCHEMBL12748758 | 0.74 | ITK (0.64) | ITKLCKTXKSYKCASP3 | |
| SCHEMBL13869803 | 0.73 | ITK (0.60) | ITKLCKTXKSYK | |
| SCHEMBL1620556 | 0.72 | ITK (0.51) | ITKLCKTXKSYKKDR | |
| SCHEMBL2903516 | 0.71 | ITK (0.47) | ITKLCKTXKSYKKDR | |
| SCHEMBL1628603 | 0.71 | ITK (0.62) | ITKLCKTXKSYK | |
| SCHEMBL2898497 | 0.70 | ITK (0.59) | ITKLCKTXKSYKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928231-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2011-04-19 | — | — | US | disclosed |