SCHEMBL16214693

SCHEMBL16214693

CCCOc1ccc(C#Cc2ccc(C(C)C(=O)NCC)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACACB O00763 18/20 0.65
GPR88 Q9GZN0 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16214700 0.89 ACACB (0.64) ACACB
SCHEMBL16214696 0.89 ACACB (0.63) ACACBGPR88
SCHEMBL16214702 0.86 ACACB (0.57) ACACBGPR88
SCHEMBL11969450 0.86 ACACB (0.58) ACACBGPR88
SCHEMBL456460 0.85 ACACB (0.65) ACACBGPR88
SCHEMBL11970046 0.83 ACACB (0.51) ACACBGPR88
SCHEMBL462901 0.81 GAA (0.47) ACACBGPR88
SCHEMBL16214694 0.81 ACACB (0.64) ACACB
SCHEMBL163363 0.79 ACACB (1.00) ACACB
SCHEMBL16214692 0.79 ACACB (0.69) ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614054-B1 ETHYNE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2014-11-19 EP disclosed
US-8877754-B2 Compounds, pharmaceutical compositions and uses thereof BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-11-04 US disclosed