Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FABP7 | O15540 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666432 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL28922840 | 0.92 | FABP7 (0.44) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16214742 | 0.89 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL17365570 | 0.84 | FKBP1A (0.43) | TSHRALDH1A1FABP7FABP5 | |
| SCHEMBL17365553 | 0.84 | FKBP1A (0.43) | TSHRALDH1A1FABP7FABP5 | |
| SCHEMBL16214759 | 0.84 | FKBP1A (0.43) | TSHRALDH1A1FABP7FABP5 | |
| SCHEMBL17365605 | 0.84 | FKBP1A (0.43) | TSHRALDH1A1FABP7FABP5 | |
| SCHEMBL1666476 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL1668432 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL1813152 | 0.80 | FABP7 (0.42) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221819-B2 | Spirocyclic compounds as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-12-29 | — | — | US | disclosed |
| US-8877749-B2 | Spirocyclic compounds as modulators of chemokine receptor activity | Bristol-Myers Squibbs Company (US) | 2014-11-04 | — | — | US | disclosed |