Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27861996 | 0.95 | MAPK1 (0.35) | POLBMAPK1LMNAL3MBTL1KMT2A | |
| SCHEMBL9898574 | 0.94 | POLB (0.39) | POLBMAPK1LMNAL3MBTL1KMT2A | |
| SCHEMBL9896573 | 0.93 | EPHX2 (0.40) | POLBMAPK1LMNAL3MBTL1KIT | |
| SCHEMBL9897502 | 0.93 | KDM2B (0.39) | POLBMAPK1LMNAL3MBTL1KMT2A | |
| SCHEMBL9896507 | 0.92 | LMNA (0.38) | POLBMAPK1LMNAL3MBTL1KIT | |
| SCHEMBL9897655 | 0.92 | MEN1 (0.40) | POLBMAPK1LMNAL3MBTL1KMT2A | |
| SCHEMBL9897041 | 0.91 | SMYD3 (0.36) | POLBMAPK1LMNAL3MBTL1KIT | |
| SCHEMBL1441879 | 0.91 | SMYD3 (0.36) | POLBMAPK1LMNAL3MBTL1KIT | |
| SCHEMBL1441884 | 0.91 | SMYD3 (0.36) | POLBMAPK1LMNAL3MBTL1KIT | |
| SCHEMBL9896746 | 0.91 | LMNA (0.37) | POLBMAPK1LMNAL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | claimed |
| CN-102574861-A | Methylpyrrolopyrimidinecarboxamides | NYCOMED GMBH | 2012-07-11 | — | — | CN | claimed |
| CN-102574861-B | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |
| CN-102574861-A | Methylpyrrolopyrimidinecarboxamides | NYCOMED GMBH | 2012-07-11 | — | — | CN | disclosed |