Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.77 |
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.62 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16226607 | 1.00 | NR1H4 (0.77) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL24198613 | 0.87 | GPBAR1 (0.82) | NR1H4GPBAR1MEN1KMT2AABCB11 | |
| SCHEMBL30555841 | 0.87 | NR1H4 (1.00) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL30555795 | 0.87 | NR1H4 (1.00) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL16227102 | 0.87 | GPBAR1 (0.70) | NR1H4GPBAR1MEN1KMT2ALMNA | |
| SCHEMBL13368620 | 0.86 | GPBAR1 (0.69) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL16226108 | 0.84 | GPBAR1 (0.74) | NR1H4GPBAR1MEN1KMT2AABCB11 | |
| SCHEMBL21026574 | 0.84 | NR3C1 (0.75) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL13240246 | 0.84 | NR3C1 (0.75) | NR1H4GPBAR1NR3C1MEN1KMT2A | |
| SCHEMBL15479183 | 0.84 | NR3C1 (0.75) | NR1H4GPBAR1NR3C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140335050-A1 | METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER | IL2RA, CD74, IL2 | NR1H4 131/4885GPBAR1 77/4885NR3C1 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.