Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | KRAS | P01116 | 16/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110398 | 0.88 | CHEK2 (0.45) | CHEK2KRASSOS1GRM2 | |
| SCHEMBL184191 | 0.86 | KMT2A (0.42) | CHEK2L3MBTL1 | |
| SCHEMBL184162 | 0.85 | CHEK2 (0.44) | CHEK2KRASGPR6 | |
| SCHEMBL1623576 | 0.83 | CHEK2 (0.41) | CHEK2KRAS | |
| SCHEMBL183847 | 0.83 | CHEK2 (0.41) | CHEK2KRASL3MBTL1 | |
| Hydrochloric Acid SCHEMBL1624492 | 0.83 | CHEK2 (0.41) | CHEK2KRAS | |
| SCHEMBL1624014 | 0.82 | SMAD3 (0.42) | CHEK2L3MBTL1 | |
| SCHEMBL1622782 | 0.81 | CHEK2 (0.54) | CHEK2L3MBTL1 | |
| SCHEMBL1623194 | 0.80 | CHEK2 (0.57) | CHEK2L3MBTL1 | |
| SCHEMBL183939 | 0.80 | CHEK2 (0.57) | CHEK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |
| US-7928107-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-19 | — | — | US | disclosed |
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | KCNQ1, KCNQ2, KCNN3 | CHEK2 2935/4885KRAS 2189/4885SOS1 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.