Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | S100A9 | P06702 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13349208 | 0.78 | DAO (0.39) | DAOMETAP2RAPGEF4S100A9TP53 | |
| SCHEMBL257059 | 0.77 | DAO (0.37) | DAOMETAP2RAPGEF4S100A9P2RX7 | |
| SCHEMBL14785249 | 0.77 | IDO1 (0.32) | — | |
| SCHEMBL16235414 | 0.77 | DAO (0.46) | DAOMETAP2S100A9 | |
| SCHEMBL17472735 | 0.73 | DAO (0.46) | DAOMETAP2BACE1 | |
| SCHEMBL10294717 | 0.72 | IDO1 (0.53) | DAOCYP3A4 | |
| SCHEMBL30342498 | 0.71 | TSHR (0.47) | DAOTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL3297906 | 0.71 | IDO1 (0.44) | DAOPOLB | |
| SCHEMBL18556911 | 0.71 | NPC1 (0.42) | RAPGEF4CYP3A4MAPK1 | |
| SCHEMBL29722898 | 0.71 | RAB9A (0.49) | DAOTP53POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |