Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.54 |
| ▸ | CDK2 | P24941 | 6/20 | 0.54 |
| ▸ | CDK4 | P11802 | 4/20 | 0.54 |
| ▸ | CCND1 | P24385 | 4/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29500202 | 1.00 | GAA (0.62) | GAAALDH1A1MAPTDCPSRAB9A | |
| Hydrochloric Acid SCHEMBL30010992 | 0.98 | GAA (0.60) | GAAALDH1A1MAPTDCPSRAB9A | |
| SCHEMBL15829295 | 0.81 | DCPS (0.57) | GAAALDH1A1MAPTDCPSRAB9A | |
| SCHEMBL28057497 | 0.80 | GAA (0.61) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL25282812 | 0.77 | GAA (0.57) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL2709303 | 0.77 | GAA (0.57) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL3119156 | 0.77 | GAA (0.57) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL14016160 | 0.77 | CCNE2 (0.58) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL31202674 | 0.77 | GAA (0.57) | GAAALDH1A1MAPTRAB9ACCNE2 | |
| SCHEMBL6405337 | 0.77 | GAA (0.57) | GAAALDH1A1MAPTRAB9ACCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114436975-B | 2-trifluoromethyl-4-aminoquinazoline compound and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-10-31 | — | — | CN | claimed |
| EP-4072670-A1 | QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-10-19 | — | — | EP | claimed |
| CN-114436975-A | 2-trifluoromethyl-4-aminoquinazoline compound and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-05-06 | — | — | CN | claimed |
| WO-2021116260-A1 | QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-06-17 | — | — | WO | claimed |
| US-12404270-B2 | Quinazoline derivatives as LPA receptor 2 inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-09-02 | — | — | US | disclosed |
| WO-2025132349-A1 | PESTICIDALLY ACTIVE QUINAZOLINE COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2025-06-26 | — | — | WO | disclosed |
| EP-4543873-A1 | PESTICIDALLY ACTIVE FUSED BICYCLIC HETEROAROMATIC COMPOUNDS | Syngenta Crop Protection AG (CH) | 2025-04-30 | — | — | EP | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| WO-2024110554-A1 | N-[(1 -[2-[6-(PYRIDAZIN-3-YL]-1,2,4-TRIAZOL-3-YL]ETHYL]-QUINAZOLIN-4-AMINE AND N-[1-[3-(6-(PYRIDAZIN-3-YL)PYRAZIN-2-YL]ETHYL]-8-QUINAZOLIN-4-AMINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION AG (CH) | 2024-05-30 | — | — | WO | disclosed |
| CN-117736207-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-03-22 | — | — | CN | disclosed |
| CN-115362003-B | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-03-22 | — | — | CN | disclosed |
| CN-117561252-A | 2- [3- [1[ (quinazolin-4-yl) amino ] ethyl ] pyrazin-2-yl ] thiazole-5-carbonitrile derivatives and similar compounds as pesticides | 先正达农作物保护股份公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-114630825-A | Pesticidally active fused bicyclic heteroaromatic compounds | 先正达农作物保护股份公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-114436975-A | 2-trifluoromethyl-4-aminoquinazoline compound and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-05-06 | — | — | CN | disclosed |
| CN-114436975-A | 2-trifluoromethyl-4-aminoquinazoline compound and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-05-06 | — | — | CN | disclosed |
| CN-114436975-A | 2-trifluoromethyl-4-aminoquinazoline compound and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-05-06 | — | — | CN | disclosed |
| EP-2611789-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030948-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
| US-20050130251-A1 | Reagent for determination of hydrogen peroxide | KYOWA MEDEX CO., LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1424554-A1 | REAGENT FOR DETERMINING HYDROGEN PEROXIDE | KYOWA MEDEX CO., LTD. (JP) | 2004-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404270-B2 | Quinazoline derivatives as LPA receptor 2 inhibitors | LPAR2, LPAR1, LPAR5 | GAA 1981/4885ALDH1A1 2204/4885MAPT 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.