Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22638717 | 0.81 | DAO (0.55) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL3060116 | 0.81 | DAO (0.44) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL2656890 | 0.80 | GAA (0.42) | KDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL6964654 | 0.78 | DAO (0.41) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL8779802 | 0.76 | KDM4E (0.40) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL2659026 | 0.75 | KMT2A (0.48) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL28225381 | 0.74 | DAO (0.56) | DAOKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL392578 | 0.74 | ALDH1A1 (0.52) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10590843 | 0.72 | CDK1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL7816128 | 0.72 | DAO (0.63) | DAOKDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105960400-B | Sulfamoylthiophene amide derivatives and its purposes for being used to treat hepatitis B as drug | 爱尔兰詹森科学公司 | 2019-05-31 | — | — | CN | disclosed |
| US-10160743-B2 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-12-25 | — | — | US | disclosed |
| EP-2997019-B1 | SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-08-08 | — | — | EP | disclosed |
| CN-105960400-A | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b | 爱尔兰詹森科学公司 | 2016-09-21 | — | — | CN | disclosed |
| US-20160115149-A1 | SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-28 | — | — | US | disclosed |
| EP-2997019-A1 | SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014184365-A1 | SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2014-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160743-B2 | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HBS1L, SLC10A1, NR1H4 | DAO 3447/4885KDM4E 1565/4885MAPT 3162/4885 |
| US-20160115149-A1 | SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HBS1L, SLC10A1, NR1H4 | DAO 3447/4885KDM4E 1565/4885MAPT 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.