SCHEMBL16238192

SCHEMBL16238192

COc1cc(OCCOC(C)(C)C)cc(OC)c1NC(=O)c1ccc(Cc2cc3c(cc2C)CCCC3(C)C)o1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 18/20 0.66
FPR1 P21462 1/20 0.66
GPR183 P32249 1/20 0.66
GPR119 Q8TDV5 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16238424 0.91 GNRHR (0.70) GNRHRFPR1GPR183GPR119
SCHEMBL16238189 0.90 GNRHR (0.69) GNRHRFPR1GPR183GPR119
SCHEMBL17549863 0.90 GNRHR (0.71) GNRHRFPR1GPR183GPR119
SCHEMBL17552135 0.90 GNRHR (0.68) GNRHRFPR1GPR183GPR119
SCHEMBL5834658 0.89 GNRHR (0.82) GNRHRFPR1GPR183GPR119
SCHEMBL16238086 0.89 GNRHR (0.65) GNRHRFPR1GPR183GPR119
SCHEMBL17549867 0.87 GNRHR (0.71) GNRHRFPR1GPR183GPR119
SCHEMBL17552170 0.86 GNRHR (0.70) GNRHRFPR1GPR183GPR119
SCHEMBL16254098 0.85 GNRHR (0.70) GNRHRFPR1GPR183GPR119
SCHEMBL16238821 0.83 GNRHR (0.53) GNRHRFPR1GPR183GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160058895-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2016-03-03 US disclosed
US-20160058895-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2016-03-03 US disclosed
US-20160058895-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2016-03-03 US disclosed
EP-2986603-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS Oslo Universitetssykehus HF (NO) 2016-02-24 EP disclosed
WO-2014184682-A9 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2015-01-29 WO disclosed
WO-2014184682-A9 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2015-01-29 WO disclosed
WO-2014184682-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2014-11-20 WO disclosed
WO-2014184682-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS OSLO UNIVERSITETSSYKEHUS HF (NO) 2014-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160058895-A1 RADIOLABELED GNRH ANTAGONISTS AS PET IMAGING AGENTS GNRHR, FSHR, GHRHR GNRHR 1/4885FPR1 759/4885GPR183 80/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.