Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16237011 | 0.91 | TOP1 (0.58) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16237107 | 0.84 | POLB (0.47) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16236552 | 0.84 | ESR1 (0.59) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16236074 | 0.83 | POLB (0.49) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16239244 | 0.82 | TOP1 (0.50) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1284160 | 0.79 | KMT2A (0.63) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL16236627 | 0.78 | HSD17B10 (0.49) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6349146 | 0.78 | POLB (0.73) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL15283463 | 0.76 | KMT2A (0.56) | POLBTOP1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6350444 | 0.76 | KMT2A (0.57) | POLBTOP1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997050-B1 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | BASELL POLIOLEFINE ITALIA SRL (IT) | 2018-01-17 | — | — | EP | disclosed |
| US-9714303-B2 | Catalyst components for the polymerization of olefins | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2017-07-25 | — | — | US | disclosed |
| US-20160115261-A1 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | Basell Poliolefine Italia, s.r.l. (IT) | 2016-04-28 | — | — | US | disclosed |
| EP-2803678-A1 | Catalyst components for the polymerization of olefins | Basell Poliolefine Italia S.r.l. (IT) | 2014-11-19 | — | — | EP | disclosed |