Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 19/20 | 0.80 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473675 | 0.93 | IMPDH2 (0.79) | IMPDH2AAK1 | |
| SCHEMBL1473676 | 0.93 | IMPDH2 (0.79) | IMPDH2AAK1 | |
| SCHEMBL5529880 | 0.89 | IMPDH2 (0.84) | IMPDH2 | |
| SCHEMBL1474100 | 0.87 | IMPDH2 (0.81) | IMPDH2IMPDH1 | |
| SCHEMBL1474101 | 0.87 | IMPDH2 (0.81) | IMPDH2IMPDH1 | |
| SCHEMBL1474078 | 0.86 | IMPDH2 (1.00) | IMPDH2AAK1 | |
| SCHEMBL1474081 | 0.86 | IMPDH2 (1.00) | IMPDH2AAK1 | |
| SCHEMBL5613824 | 0.86 | IMPDH2 (1.00) | IMPDH2 | |
| SCHEMBL5531702 | 0.85 | IMPDH2 (0.85) | IMPDH2AAK1 | |
| SCHEMBL5535695 | 0.84 | IMPDH2 (0.76) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2803357-B1 | Angiogenesis inhibitors | UNIV JOHNS HOPKINS (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-2803357-A2 | Angiogenesis inhibitors | THE JOHNS-HOPKINS UNIVERSITY (US) | 2014-11-19 | — | — | EP | disclosed |