Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363727 | 0.89 | SCN9A (0.64) | SCN9AHDAC8SCN5A | |
| SCHEMBL16239966 | 0.84 | HDAC8 (0.65) | SCN9AHDAC8SCN5A | |
| Diethylamine SCHEMBL16239800 | 0.84 | SCN9A (0.59) | SCN9AHDAC8SCN5A | |
| SCHEMBL366237 | 0.83 | HDAC8 (0.51) | SCN9AHDAC8SCN5A | |
| SCHEMBL366085 | 0.83 | SCN9A (0.58) | SCN9AHDAC8SCN5A | |
| SCHEMBL16239813 | 0.83 | HDAC8 (0.63) | SCN9AHDAC8 | |
| SCHEMBL680292 | 0.82 | SCN9A (0.65) | SCN9ASCN5A | |
| SCHEMBL680427 | 0.82 | SCN9A (0.59) | SCN9ASCN5A | |
| SCHEMBL16240196 | 0.82 | SCN9A (0.77) | SCN9ASCN5A | |
| SCHEMBL16618352 | 0.81 | SCN9A (1.00) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593428-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |