SCHEMBL16239773

SCHEMBL16239773

COc1ccc(F)c(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2F)c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.60
SCN5A Q14524 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16240231 0.93 SCN9A (0.56) SCN9ASCN5A
SCHEMBL16239717 0.88 SCN9A (0.57) SCN9ASCN5A
SCHEMBL16239596 0.87 SCN9A (0.56) SCN9ASCN5A
SCHEMBL16239745 0.84 SCN9A (0.74) SCN9ASCN5A
SCHEMBL16240262 0.84 SCN9A (0.74) SCN9ASCN5A
SCHEMBL16239610 0.84 SCN9A (0.74) SCN9ASCN5A
SCHEMBL14890193 0.84 SCN9A (0.58) SCN9ASCN5A
SCHEMBL16239726 0.83 SCN9A (0.55) SCN9ASCN5A
SCHEMBL16239953 0.83 SCN9A (0.57) SCN9ASCN5A
SCHEMBL16239961 0.83 SCN9A (0.56) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593428-B1 N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS PFIZER LTD (GB) 2014-11-19 EP disclosed